In Nature Communications, the researchers report the ovaries they constructed housed eggs, boosted hormone production, and restored fertility in female mice. The mice carried their offspring, gave birth, and even successfully nursed their young. It's a good sign for women who struggle to become pregnant after undergoing cancer treatments. According to the American Cancer Society, the majority of chemotherapy drugs have been shown to cause egg damage and infertility.
"What happens with some of our cancer patients is that their ovaries don't function at a high enough level and they need to use hormone replacement therapies in order to trigger puberty," said Monica Laronda, co-lead author of the study who is now with the Ann & Robert H. Lurie Children's Hospital, in a news release.
"Using bioengineering, instead of transplanting from a cadaver, to create organ structures that function and restore the health of that tissue for that person, is the holy grail of bioengineering for regenerative medicine," said Teresa K. Woodruff, a reproductive scientist and director of the Women's Health Research Institute at Northwestern University's Feinberg School of Medicine
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